课程文献中心 更多>>

关键词： 屋顶节能   地面节能   墙体节能  

摘要： 近期,国务院印发了《2030年前碳达峰行动方案》(国发〔2021〕23号),明确指出要"深入挖潜存量项目,加快淘汰落后产能,通过改造升级挖掘节能减排潜力",坚决遏制"两高"项目盲目发展;国家发展改革委等五部门印发了《关于严格能效约束推动重点领域节能降碳的若干意见》(发改产业〔2021〕1464号),并配套发布《冶金、建材重点行业严格能效约束推动节能降碳行动方案(2021-2025年)》,强调要"引导低效产能有序退出".

关键词： 生物质   农业废弃物   压缩成型   屋顶绿化   配合比   成型工艺参数  

摘要： 屋顶绿化可有效减少城市径流,减缓热岛效应和温室效应。为了解决屋顶绿化散体基质施工难度大、成本高等问题,该研究以生物质灰为主要原材料,辅以小麦秸秆和污泥,压缩为屋顶绿化基质底部加强层,并分别从粘结剂优选、配合比优化和压缩工艺参数优化3个方面对基质加强层的抗破坏强度进行了研究。结果表明:1)添加比例为4%的黄原胶对生物质灰成型块的抗破坏能力提升较高,抗弯强度和抗剪强度较对照分别提升了360.9(27.98倍)和355.8 N(32.94倍)。2)当生物质灰、小麦秸秆和污泥体积比为4∶1∶1(干物质量之比12.42∶1∶2.14)时,基质加强层抗弯强度和抗剪强度的试验观测数值达到最大值,分别为93.1和38.4 N;Scheffe三元二次多项式模拟结果显示,松弛密度的主要影响成分为秸秆(系数4.2),抗弯强度主要由生物质灰和秸秆共同影响(系数451),抗剪强度主要由秸秆和污泥共同影响(系数197.2),优化配比结果为生物质灰、小麦秸秆和污泥体积比3∶1∶1(干物质量之比9.31∶1∶2.14)。3)正交试验的分析结果表明,基质加强层的最优压缩工艺参数为混合原材料含水率25%、成型温度80℃、成型压力120 kN、保压时间5 min、105℃恒温加热烘干,此时抗弯强度和抗剪强度分别为184.6和162.7 N。该研究可为屋顶绿化加强层的机械化装配施工奠定配合比和压缩工艺基础,并为生物质灰等农业废弃物的资源化利用提供新思路。

关键词： 建筑设计   立体构成   立体造型   概念要素   建筑立面设计   表现形式   相似性   点、线、面  

摘要： 立体构成是研究空间立体造型的学科,通过概念要素的重新组合,即用点、线、面、体这些纯粹的概念要素的运动变化构成新的形态,与建筑设计具有一定相似性,即建筑是抽象的构成应用于生活中的一种具体表现形式。将其作用于建筑设计中,不仅能合理地构成建筑空间,还能带来建筑形象的“美”。

关键词： 南京长江大桥   双曲拱桥   桥面铺装   钢筋混凝土板   伸缩缝   改造   研究  

摘要： 南京长江大桥公路落地引桥及分叉落地桥均采用具有我国民族特色的双曲拱桥。南京长江大桥双曲拱桥以及有填料的上承式拱桥,均存在因填料跨墩连续铺筑产生的主墩处的横桥向裂缝所导致的铺装体系耐久性破坏问题。本次改造设计对拱上建筑进行了彻底改造:拱上填料更换为泡沫混凝土,顶面增设钢筋混凝土板及双层沥青。通过对桥面铺装层体系进行方案深入比选以及对桥面进行合理分联设缝,优化了结构受力状态,杜绝了桥面病害。

关键词： Microglia   Nestin   α-internexin   Neurogenesis   PI3K   AKT   NEURAL PRECURSOR CELLS   CENTRAL-NERVOUS-SYSTEM   SUBVENTRICULAR ZONE   PROGENITOR CELLS   DIFFERENTIAL REGULATION   NEURONAL DEGENERATION   SYNAPSE FORMATION   ADULT   ACTIVATION   CNS  

摘要： Emerging evidence suggests that microglia can support neurogenesis. Little is known about the mechanisms by which microglia regulate the cortical environment and stimulate cortical neurogenesis. We used an in vitro co-culture model system to investigate the hypothesis that microglia respond to soluble signals from cortical cells, particularly following mechanical injury, to alter the cortical environment and promote cortical cell proliferation, differentiation, and survival. Analyses of cortical cell proliferation, cell death, neurogenic protein expression, and intracellular signaling were performed on uninjured and injured cortical cells in co-culture with microglial cell lines. Microglia soluble cues enhanced cortical cell viability and proliferation cortical cells. Co-culture of injured cortical cells with microglia significantly reduced cell death of cortical cells. Microglial co-culture significantly increased Nestin + and alpha-internexin + cortical cells. Multiplex ELISA and RT-PCR showed decreased pro-inflammatory cytokine production by microglia co-cultured with injured cortical cells. Inhibition of AKT phosphorylation in cortical cells blocked microglial-enhanced cortical cell viability and expression of neurogenic markers in vitro. This in vitro model system allows for assessment of the effect of microglial-derived soluble signals on cortical cell viability, proliferation, and stages of differentiation during homeostasis or following mechanical injury. These data suggest that microglia cells can downregulate inflammatory cytokine production following activation by mechanical injury to enhance proliferation of new cells capable of neurogenesis via activation of AKT intracellular signaling. Increasing our understanding of the mechanisms that drive microglial-enhanced cortical neurogenesis during homeostasis and following injury in vitro will provide useful information for future primary cell and in vivo studies.

关键词： RITUXIMAB  

关键词： B-cell   Diffuse large B-cell lymphoma   Primary intestinal lymphomas   Prognosis   T-cell   NON-HODGKINS-LYMPHOMA   POPULATION-BASED ANALYSIS   GASTROINTESTINAL-TRACT   T-CELL   MALIGNANT-LYMPHOMA   INVOLVEMENT   MULTICENTER   SURVIVAL  

摘要： Background: Primary intestinal lymphomas (PILs) are rare, and this study compared the clinical outcomes of aggressive primary intestinal B-cell lymphomas (aB-PILs) and T/natural killer-cell lymphomas (T/NK-PILs). Methods: The clinical information of patients diagnosed with aggressive PILs at our institution between 1995 and 2015 were retrospectively investigated. Pathological subtypes were confirmed according to the 2016 revision of the World Health Organization classification. The correlation between clinicopathological features and overall survival (OS) was determined using univariate and multivariate analyses. Results: Cases of T/NK-PILs had higher initial bowel perforation incidence (67% vs. 7%, P < 0.001) and lower complete response rate to first-line chemotherapy regimens (22% vs. 69%, P = 0.009) than aB-PILs. Patients with aB-PILs had a better 5-year event-free survival rate (55.8% vs. 13.9%, P = 0.026) and a 5-year OS rate (74.3% vs. 29.6%, P = 0.036) than those with T/NK-cell lymphomas. Multivariate analysis identified that female gender and stage were unfavorable prognostic factors. Among the 54 patients with diffuse large B-cell lymphoma (DLBCL), those with International Prognostic Index (IPI) scores of 0-2 had a better 5-year OS rate than those with scores of 3-5 (84.2% vs. 46.8%, P = 0.002). IPI scores of 3-5 (P = 0.026) and tumors located in the large intestine (P = 0.015) were poor prognostic factors based on the multivariate analysis. Conclusion: The prognosis of T/NK-PILs was less favorable than that of aB-PILs. Female gender, stage III/IV disease, DLBCL with IPI scores of 3-5, or tumors in the large intestine were poor prognostic factors. Copyright (C) 2020, Formosan Medical Association. Published by Elsevier Taiwan LLC.

关键词： Capilliposide B   Proliferative diabetic retinopathy   VEGF   VEGFR2   Akt   Erk   Migration   Proliferation   Tube formation   GROWTH-FACTOR   ORF VIRUS   SAPONINS   PROTEIN   PHOSPHORYLATION   BEVACIZUMAB   RECEPTOR-2   ACTIVATION   EXPRESSION   AKT/PKB  

摘要： Abnormal angiogenesis is associated with intraocular diseases such as proliferative diabetic retinopathy and neovascular age-related macular degeneration, and current therapies for these eye diseases are not satisfactory. The purpose of this study was to determine whether capilliposide B (CPS-B), a novel oleanane triterpenoid saponin derived from Lysimachia capillipes Hemsl, can inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis signaling events and cellular responses in primary human retinal microvascular endothelial cells (HRECs). Our study revealed that the capilliposide B IC50 for HRECs was 8.5 mu M at 72 h and that 1 mu M capilliposide B specifically inhibited VEGF-induced activation of VEGFR2 and its downstream signaling enzymes Akt and Erk. In addition, we discovered that this chemical effectively blocked VEGF-stimulated proliferation, migration and tube formation of the HRECs, suggesting that capilliposide B is a promising prophylactic for angiogenesis-associated diseases such as proliferative diabetic retinopathy.

关键词： Primary immunodeficiency   post-transplant autoimmunity   children   BONE-MARROW-TRANSPLANTATION   THYROID-DYSFUNCTION   DISEASES  

摘要： Purpose Knowledge of post-hematopoietic cell transplantation (HCT) non-hematological autoimmune disease (AD) is far from satisfactory. Method This multicenter retrospective study focuses on incidence, risk factors, and outcomes of post-HCT AD in 596 children with primary immunodeficiency (PID) who were transplanted from 2009 to 2018. Results The indications of HCT were severe combined immunodeficiency (SCID, n = 158, 27%) and non-SCID PID (n = 438, 73%). The median age at HCT was 2.3 years (range, 0.04 to 18.3 years). The 5-year overall survival for the entire cohort was 79% (95% cumulative incidence (CIN), 74-83%). The median follow-up of surviving patients was 4.3 years (0.08 to 14.7 years). The CIN of post-HCT AD was 3% (2-5%) at 1 year post-HCT, 7% (5-11%) at 5 years post-HCT, and 11% (7-17%) at 8 years post-HCT. The median onset of post-HCT AD was 2.2 years (0.12 to 9.6 years). Autoimmune thyroid disorder (n = 19, 62%) was the most common post-HCT AD, followed by neuromuscular disorders (n = 7, 22%) and rheumatological manifestations (n = 5, 16%). All patients but one required treatment for post-HCT AD. After multivariate analysis, age at transplant (p = 0.01) and T cell-depleted graft (p < 0.001) were significant predictors of post-HCT AD. None of the T cell-depleted graft recipients developed post-HCT AD. Patients with a lower CD3+ count at 6 months post-HCT had a significant higher incidence of post-HCT AD compared to disease controls. Graft-versus-host disease, viral infection, and donor chimerism had no association with post-HCT AD. Conclusion Post-HCT AD occurred in 11% at 8 years post-HCT and its occurrence was associated with older age at HCT and unmanipulated graft.