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关键词： 蒸压加气混凝土   隔墙板   砌块墙体  

摘要： 蒸压加气混凝土隔墙板是具有保温隔热性能强、施工效率高、施工成型质量优异等优良性能的绿色建材。以灵山岛金茂湾项目蒸压加气混凝土隔墙板施工应用为研究对象,通过与传统普通砌筑施工应用进行比较研究分析,主要分析内容如下:蒸压加气混凝土隔墙板材与传统普通砌筑材料外观尺寸偏差、性能要求差异,施工质量与劳动力计划分析,施工进度、成本分析。研究结果表明:在材料外观尺寸偏差、各性能要求方面不相上下,施工过程质量不可控因素少,便于现场管理,垂直平整度、成型效果优异,劳动力投入较少,施工效率高,成本可控,综合效益高,属于经济性墙体,具有良好的工程应用价值。

关键词： 菊花   阳台   花草   《诗经》  

摘要： 妈妈平日里侍弄花草,常常忘却门边放着的一盆尚未开放、不起眼的菊花。起初,我对它也没太多好感。别的花早开了,它却只有光秃秃的枝条懒懒地倚在门旁,微微散开,像蓬乱的头发。一个阳光明媚的下午,我静静地躺在阳台的摇椅上,沐浴阳光,欣赏阳台上的花草。不经意间,我的目光落在了那盆菊花上。在阳光的照射下,它那墨绿的茎叶变得浓翠欲滴;微风拂过,它开始扭动柔嫩的腰肢翩翩起舞。我联想到了《诗经》中的静女。

关键词： 改性沥青   桥梁伸缩缝   常见病害   养护要点  

摘要： 桥梁伸缩缝的存在是为了满足桥面变形需求,作为桥梁的重要组成部分之一,桥梁伸缩缝一般设置在梁端与桥台之间,需满足车辆平顺行驶、防止雨水渗透、易于检查养护等条件。日常桥梁伸缩缝的养护是维持其正常功能的基础条件,对于确保行车舒适度和行车安全具有重要意义,本文以近几年昆山市区三里桥、玉龙桥等几座桥梁为例,就改性沥青桥梁伸缩缝常见的一些问题及养护方法展开论述,期望可以为相关从业人员提供参考。

关键词： 伸缩缝施工   市政道路桥梁   道路桥梁施工  

摘要： 由于市政道路桥梁需要长期可靠运行,这就要求建设单位必须从长远发展的角度设计市政道路的施工方案,施工人员应按照方案要求,控制施工的各个环节,特别是各种施工技术的准确应用,从而减少外部因素的干扰,避免施工质量问题的发生。伸缩缝施工工艺受施工环境温度影响较大,伸缩缝施工也关系到市政道路的运营安全。因此,在实际伸缩缝施工中,要做好施工前的各项准备工作,准确应用切缝开槽技术,注意型钢变形的校核,做好后期伸缩缝的维护管理工作,从而提高伸缩缝的施工质量。

关键词： Correlative imaging   DNA-PAINT   Live cell imaging   Calcium imaging   Myocytes   CALCIUM SPARKS   CA2+ SPARKS   MICROSCOPY   CLUSTERS   HEART   DNA  

摘要： Nanometre-scale cellular information obtained through super-resolution microscopies are often unaccompanied by functional information, particularly transient and diffusible signals through which life is orchestrated in the nano-micrometre spatial scale. We describe a correlative imaging protocol which allows the ubiquitous intracellular second messenger, calcium (Ca2+), to be directly visualised against nanoscale patterns of the ryanodine receptor (RyR) Ca2+ channels which give rise to these Ca2+ signals in wildtype primary cells. This was achieved by combining total internal reflection fluorescence (TIRF) imaging of the elementary Ca2+ signals, with the subsequent DNA-PAINT imaging of the RyRs. We report a straightforward image analysis protocol of feature extraction and image alignment between correlative datasets and demonstrate how such data can be used to visually identify the ensembles of Ca2+ channels that are locally activated during the genesis of cytoplasmic Ca2+ signals.

关键词： Phenotype   Clustering   Cell tracking   Cell morphology   Cell motility   STOPPING RULES   COCULTURE   NUMBER   SHAPE  

摘要： In vitro cell culture model systems often employ monocultures, despite the fact that cells generally exist in a diverse, heterogeneous microenvironment in vivo. In response, heterogeneous cultures are increasingly being used to study how cell phenotypes interact. However, the ability to accurately identify and characterize distinct phenotypic subpopulations within heterogeneous systems remains a major challenge. Here, we present the use of a computational, image analysis-based approach-comprising automated contour-based cell tracking for feature identification, principal component analysis for feature reduction, and partitioning around medoids for subpopulation characterization-to non-destructively and non-invasively identify functionally distinct cell phenotypic subpopulations from live-cell microscopy image data. Using a heterogeneous model system of endothelial and smooth muscle cells, we demonstrate that this approach can be applied to both mono and co-culture nuclear morphometric and motility data to discern cell phenotypic subpopulations. Morphometric clustering identified minimal difference in mono- versus co-culture, while motility clustering revealed that a portion of endothelial cells and smooth muscle cells adopt increased motility rates in co-culture that are not observed in monoculture. We anticipate that this approach using non-destructive and non-invasive imaging can be applied broadly to heterogeneous cell culture model systems to advance understanding of how heterogeneity alters cell phenotype.

关键词： HIGH-RISK   SUNITINIB   PLACEBO  

摘要： Take Home MessageAdjuvant therapy with antiangiogenic agents in locoregional renal cell carcinoma did not translate into a sufficient benefit and highlight the crucial role of patient selection. Ongoing clinical trials with immune-targeted agents hold great promise for this unmet clinical need.

关键词： Primary renal tumour   Renal cell carcinoma   Nivolumab   Cytoreductive nephrectomy   Immune checkpoint inhibitors   CYTOREDUCTIVE NEPHRECTOMY  

摘要： Primary tumour response may impact therapeutic strategies in metastatic renal cell carcinoma (mRCC) but remains unknown in the era of immune checkpoint inhibitors. We aimed to describe the response of the primary tumour in patients who did not undergo upfront cytoreductive nephrectomy (uCN) and were treated with nivolumab in the GETUG-AFU-26 NIVOREN phase 2 trial. Primary tumour response was prospectively assessed, as well as the overall response rate (ORR), progression-free survival (PFS), and overall survival (OS). Among 720 patients, 111 did not undergo uCN, mainly patients with intermediate (45%) and poor (49%) International mRCC Database Consortium (IMDC) risk. In the 111 patients, nivolumab was used in the second line for 63% of patients and the third line or more for 37%, with an ORR of 16% (95% confidence interval ICI] 1025%); with a median follow-up of 24.5 mo (95% CI 21.6-27.1), median PFS was 2.7 mo (95% CI 2.5-4.0) and median OS was 15.9 mo (95% CI 9.5-19.8). A total of 67 patients had an evaluable primary renal lesion, four of whom (6%) experienced shrinkage of more than 30%. Overall, patients who did not undergo uCN had adverse baseline characteristics and nivolumab activity against the primary tumour was limited. Patient summary: In this report, we observed that nivolumab was associated with a limited response of the primary tumour in previously treated patients with metastatic kidney cancer. (c) 2021 Published by Elsevier B.V. on behalf of European Association of Urology.

关键词： Primary mediastinal B cell lymphoma   MACOP-B   Rituximab   Radiotherapy   Checkpoint inhibitor  

摘要： Primary mediastinal B cell lymphoma is a rare entity and often should be promptly treated as a hematological emergency: The initial treatment decision is crucial for the management of this disease. An observational retrospective study was conducted with the aim to improve information on treatment and outcomes of primary mediastinal B cell lymphoma in real practice. After 12 cycles of MACOP-B regimen (methotrexate, doxorubicin, cyclophosphamide, vincristine, , and prednisone) with or without rituximab, 120 patients out of 151 (79.5%) achieved a complete response and 12 (7.9%) a partial response leading to a global response of 87.4%. The 21-year overall survival is 82.6%; progression-free and disease-free survivals are 69.3% and 86.4%, respectively. Regarding the role of radiotherapy (RT), patients with a negative PET scan after MACOP-B did not undergo RT: One out of these 48 (2.1%) showed a relapse at 11 months. All relapsed/refractory patients who achieved a response with checkpoint inhibitors are still in continuous complete response with a median follow-up of 14 months. Data that we have gathered over a 30-year experience in the treatment of primary mediastinal B cell lymphoma patients clearly indicate that a third-generation chemotherapy regimen such as MACOP-B is feasible and easily deliverable on an outpatient basis. Regarding the unmet medical need of relapsed/refractory patients, new encouraging results occurred with the advent of the checkpoint inhibitors.

关键词： arborizing vessels   basal cell carcinoma   BCC   blue-white veil   concentric structures   corkscrew vessels   dermatoscopy   dermoscopy   dotted vessels   glomerular vessels   hairpin vessels   infiltrative basal cell carcinoma   large blue-grey ovoid nests   leaf-like areas   morpheaform basal cell carcinoma   multiple blue-grey dots and globules   multiple in-focus dots   multiple small erosions   nodular basal cell carcinoma   nonpigmented basal cell carcinoma   pigmented basal cell carcinoma   polymorphous vessels   rosettes   shiny white structures   shiny white-red structureless background   short-fine telangiectasia   spoke wheel areas   superficial basal cell carcinoma   ulceration   VASCULAR STRUCTURES   SKIN TUMORS   DIAGNOSIS   DERMATOSCOPY   PIGMENTATION   MICROSCOPY   LOCATION   PATTERNS   SURFACE  

摘要： Background: Multiple studies have reported on dermoscopic structures in basal cell carcinoma (BCC) and its subtypes, with varying results. Objective: To systematically review the prevalence of dermoscopic structures in BCC and its subtypes. Methods: Databases and reference lists were searched for relevant trials according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies were assessed for the relative proportion of BCC dermoscopic features. Random-effects models were used to estimate summary effect sizes. Results: Included were 31 studies consisting of 5950 BCCs. The most common dermoscopic features seen in BCC were arborizing vessels (59%), shiny white structures (49%), and large blue-grey ovoid nests (34%). Arborizing vessels, ulceration, and blue-grey ovoid nests and globules were most common in nodular BCC; short-fine telangiectasia, multiple small erosions, and leaf-like, spoke wheel and concentric structures in superficial BCC; porcelain white areas and arborizing vessels in morpheaform BCC; and arborizing vessels and ulceration in infiltrative BCC. Limitations: Studies had significant heterogeneity. Studies reporting BCC histopathologic subtypes did not provide clinical data on pigmentation of lesions. Conclusion: In addition to arborizing vessels, shiny white structures are a common feature of BCC. A constellation of dermoscopic features may aid in differentiating between BCC histopathologic subtypes.