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关键词： 桥梁伸缩缝   密封胶   免维护技术   施工工艺  

摘要： 桥梁伸缩缝在适应桥梁温度变形、防水防尘以及车辆冲击力等方面都发挥着至关重要的作用,但在实际应用过程中,胶条损坏问题却经常出现。结合沈吉高速养护项目,详细介绍了采用单组份聚氨酯密封胶灌封桥梁伸缩缝的施工工艺,并从技术方面、经济方面,分析了桥梁伸缩缝免维护技术的优势。

关键词： 伸缩缝   破坏机理   影响因素   修复措施  

摘要： 伸缩缝是桥梁上部主体结构的一个重要组成部分,对于保证桥梁结构稳定、行车安全等具有重要意义。然而,在自然环境和道路交通运行荷载的共同作用下,伸缩缝装置会出现不同程度的破坏,导致桥梁使用寿命降低。本文以介绍桥梁伸缩缝的类型为出发m,总结桥梁伸缩缝的主要破坏形式和破坏机理,从设计施工、材料和养护管理等方面对伸缩缝损坏的原因进行探讨,并从结构和材料两个方面提出修复措施,旨在为桥梁伸缩缝的深入研究提供借鉴和参考。

关键词： 大层高   内隔墙   蒸压加气混凝土  

摘要： 随着产业不断集中化,大型厂房的建设需求越来越多,为节约建设项目成本及贯彻绿色建筑理念,需从设计施工的角度优化建设工程。对于层高较高的物流厂房,传统砌筑内隔墙工序多、操作不便、湿作业对环境影响不利;相比之下,从厂家预制到施工现场拼装的预制蒸压加气混凝土板有工序简单、施工快速、干作业等诸多优点,是一项优秀的工程优化措施。

关键词： 系统设计   智能安防   电动围栏  

摘要： 本文探讨基于万物互联技术控制的阳台电动围栏系统,该系统由通过各类传感器及云平台触发,主动实现电动围栏的开合,正常状态下该围栏收卷并隐藏在阳台两侧,当发现儿童独自逗留在阳台或者阳台外有非法入侵者时,该围栏自动滑出轨道,形成阳台封闭,并同时发送信息至用户手机端。

关键词： Intensity-modulated radiotherapy   locally advanced   outcomes   sinonasal squamous cell carcinoma   PROTON-BEAM THERAPY   PARANASAL SINUS   NASAL CAVITY   CONCURRENT CHEMORADIOTHERAPY   TUMORS   SURVIVAL   CANCER   EPIDEMIOLOGY  

摘要： Aims: Sinonasal malignancies are rare; the most common histological subtype is squamous cell carcinoma (SCC). No randomised trial data exist to guide treatment decisions, with options including surgery, radiotherapy and chemotherapy. The role and sequence of a primary non-surgical approach in this disease remains uncertain. The aim of this study was to present treatment outcomes for a multicentre population of patients with locally advanced, stage IVa/b sinonasal SCC treated with radical-intent intensity-modulated radiotherapy, either definitively or postoperatively. Materials and methods: Consecutively treated patients with locally advanced, stage IVa/b sinonasal SCC at four UK oncology centres between January 2012 and December 2017 were retrospectively identified. Descriptive statistics and survival analyses were carried out. Univariable Cox regression analysis was carried out to evaluate the relationship between patient, disease and treatment factors and survival outcomes. Results: In total, 56 patients with sinonasal SCC were included (70% maxillary sinus, 21% nasal cavity, 9% ethmoid/frontal sinus). Forty-one patients (73%) were treated by surgery/adjuvant (chemo)radiotherapy and 15 (27%) by definitive (chemo)radiotherapy. The median duration of follow-up was 3.8 years (interquartile range 2.0-4.7 years). Estimates for 5-year overall survival and progression-free survival were 30.2% and 24.2%, respectively. Local, regional and distant treatment failures were seen in 33%, 33% and 16% of patients, respectively. Univariable analysis revealed inferior progression-free survival for patients treated with neck dissection (hazard ratio 2.6, 95% confidence interval 1.2-6.1, P = 0.022) but no other significant association between the studied factors and survival outcomes. Conclusion: We show poor survival outcomes and high rates of locoregional treatment failure for patients with locally advanced stage IVa/b sinonasal SCC. There is a need to investigate improved treatmen

关键词： Tumor Necrosis Factor-alpha   Cerebral Ischemia   Mesenchymal Stem Cell transplantation   Microglia   Astrocyte   NECROSIS-FACTOR-ALPHA   INFLAMMATORY RESPONSE   BRAIN   MICROGLIA   BLOOD   POLARIZATION   BARRIER   DISEASE  

摘要： Recent studies report that inhibiting TNF-alpha might be a novel therapeutic strategy for managing brain ischemia. Our previous study reported that mesenchymal stem cell (MSC) transplantation could suppress TNF-alpha level in both serum and brain. However, the cell type(s) that contribute to the production of TNF-alpha during ischemia following MSC transplantation has not been well studied. In the present study, we found by fluorescent immunohistochemistry, that 7.95 +/- 6.17% of TNF-alpha(+) cells co-expressed Iba-1 in the infarct area of dMCAO rats, a majority of which were found to be CD68(+) (activated microglia), suggesting that resident microglial population were not the major source of TNF-alpha expression. 68.49 +/- 5.12% of the TNF-alpha(+) cells in the infarct area could be labeled by GFAP, a specific marker for astrocytes, indicating that resident GFAP(+) astrocytes might be the major source of TNF-alpha expression in the infarct area. In addition to the infarct area, the GFAP(+)/TNF-alpha(+) double-positive astrocytes accounted for 73.68 +/- 7.48% of the TNF-alpha(+) cells in striatum and corpus callosum. The infiltrating cells, including monocytes and lymphocytes, were not the main source of TNF-alpha either. In response to MSC transplantation, the total TNF-alpha(+) cells as well as the percentage of TNF-alpha-expressing astrocytes were significantly reduced in the infarct area, suggesting that MSC transplantation could suppress the expression of TNF-alpha by astrocytes. Taken together, the results demonstrated that resident astrocytes, but not microglia, were the major source of TNF-alpha expression and could be suppressed by MSC infusion.

摘要： Prolonged complete remissions (CRs) are rare in advanced-stage cutaneous T-cell lymphomas (CTCLs). Ifosfamide + etoposide (I+E) have been used to treat lymphomas, combined with platinum-based agents in Hodgkin disease or non-Hodgkin lymphomas including peripheral T-cell lymphomas. Monoclonal antibodies have induced long-term remissions in CTCL but are usually poorly effective in transformed disease Allogeneic haematopoietic stem cell transplantation (alloHSCT) holds a potential for cure but relies on the existence of a pretransplant CR, which may require the use of chemotherapeutic regimens. To our knowledge, to date there are no published data on I+E efficacy and tolerance in advanced refractory CTCL. We performed a retrospective monocentre study on 28 patients with mycosis fungoides (MF, n=15) or Sézary syndrome (SS, n=13) treated with I+E between 2012 and 2019. In this study, I+E showed antitumor activity in these heavily pretreated patients with CTCL, with an ORR of 43%, and no significant difference between the full-dose and reduced-dose regimens in terms of ORR or SAE frequencies, indicating that the reduced regimen may be a suitable option in fragile patients. In conclusion, I+E is a valuable therapeutic option in patients with advanced, refractory CTCL.

关键词： macule   patch   primary cutaneous B-cell lymphoma   follicle center-cell lymphoma   marginal-zone lymphoma  

摘要： Importance:Primary cutaneous B-cell lymphoma (PCBCL) classically presents with papules, plaques, nodules/ tumors. Previous reports of PCBCL manifesting with macular lesions are scarce, and focused on primary cutaneous follicle-center cell lymphoma (PCFCL), with limited data on its clinicopathological correlation. Objective:To report our experience with PCBCL presenting with erythematous macules. Design:Retrospective cohort. Setting:Two tertiary cutaneous-lymphoma outpatient clinics. Participants:Fourteen patients with low-grade PCBCL manifesting with erythematous patches, diagnosed and managed between January 2000 and December 2019. Intervention:Clinical data were collected from the medical files. Biopsy specimens of the macules, and if present of the typical nodular/tumoral lesions, were reviewed. Main outcome measures:Characterizing the macular lesions of low-grade PCBCL. Results:There were 14 patients, aged 16–67 years, 8 had PCFCL and 6 had primary cutaneous marginal zone lymphoma (PCMZL). All had erythematous macules, measuring 1–15 cm, which mimicked: figurate erythema, interstitial granuloma annulare, livedo reticularis, vascular tumors, and in 7 patients showed also follicular accentuation, thus simulated early-stage folliculotropic mycosis fungoides. In 3 patients macules were the presenting lesions, in 2 as the sole manifestation, whereas in 12 patients typical PCBCL lesions were observed during the disease course. On histopathology, the macular lesions showed in all superficial and deep perivascular infiltrates and in all but 1 also periadnexal lymphoid infiltrates. Microdules were observed in 11 biopsy specimens, in only 4 of them nodular infiltrates were also observed B-cells comprised the majority of the lymphocytes in only 4 patients, while in the remaining 10, B and T-cells were either equally distributed or T-cells outnumbered B. Polymerase-based analysis of a patch showed immunoglobulin heavy chain monoclonality in 7 of 11 cases tested. Conclusions

关键词： Primary nephrotic syndrome   Children   B cells   Follicular helper T cells   LYMPHOCYTE POPULATIONS   IMMUNE-SYSTEM  

摘要： The immunopathogenesis of primary nephrotic syndrome is unclear. Here, we examined the frequency, subsets and molecular function of circulating B cells and follicular helper T cells by flow cytometry and explored the correlation between certain subsets and clinical disease indices in new-onset patients, relapsing patients and healthy controls. We found an increase in the proportions of CD86(+) activated cells and CD19(+)CD138(+) plasma cells in the patients at onset and patients in relapse. However, the increased percentage of CD27(+) memory cells was observed in only the relapse group. Furthermore, the ICOS MFI was elevated in TFH cells and their three subsets in new-onset patients, whereas the expression of OX40 was increased in TFH cells, TFH17 cells and TFH2 cells in the relapse group. Additionally, the increased frequency of CD19(+)CD138(+) plasma cells was positively associated with urea nitrogen in the new-onset groups. Notably, the positive correlation between CD86(+) activated B cells and CD19(+)CD138(+) plasma cells was obtained in only the new-onset group and HC group; however, the increased CD27(+) memory cell percentage was positively correlated with 24-h urinary protein in only the relapse group. Our results indicate that CD19(+)CD138(+) plasma cells may be a key factor for the onset of PNS, whereas CD27(+) memory cells may play a more important role in the relapse of this disease. Furthermore, the functions of TFH cells are also diverse because the expression of vital molecules changes during the different disease phases.