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关键词： 城市有机更新   下沿街   建筑立面   立面改造   设计方法  

摘要： 基于城市有机更新条件下,各城市在创新发展过程中均对城市形象进行创新设计,目的是能在视觉及建筑特点上给人带来较强的视觉感,充分展现出城市特色、风格,与现代化城市创新发展的目标相同.对此,在沿街建筑立面改造设计方面,依据各项原则重点探究设计内容,在整个设计环节中能保证旧城区建筑历史元素与创新价值,尽量不破坏旧城区建筑原有结构的同时完成创新工作.

关键词： PEM Fuel cell   Hydrogen   Thermodynamic modelling   Range extenders   Hybrid electric vehicles   ENVIRONOMIC DESIGN   OPTIMIZATION  

摘要： Significant research efforts have been invested in the automotive industry on hybrid-electrified pow-ertrains in order to reduce the passenger cars' dependence on oil. Powertrains electrification resulted in a wide range of hybrid vehicle architectures. Fuel consumption of these powertrains strongly relies on the energy converters performance, as well as on the energy management strategy deployed on-board. This paper investigates the potential of energy consumption savings of a serial hybrid electric vehicle (SHEV) using a hydrogen proton-exchange membrane fuel cell (PEMFC) as energy converter operating as an auxiliary power unit (APU) instead of the conventional internal combustion engine (ICE). A PEMFC model is developed and the thermodynamic system efficiency is simulated. The PEMFC APU is integrated in the modelled SHEV powertrain. The hydrogen stored on board is gaseous and pressurized under 700 bars. Energy consumption simulations are performed on WLTP cycle with 4 different battery capacities using dynamic programing as global optimal energy management strategy. The results show improved effi-ciency with PEMFC as an auxiliary power unit (APU) compared to ICE. The auxiliary power unit consumes less than 1 kg/100 km of hydrogen on a normalized cycle. The integration of an additional power unit based on PEMFC is studied as a solution for the extension of the range of the electric vehicles. (c) 2021 Elsevier Ltd. All rights reserved.

关键词： ALC隔墙板   板缝处理   施工质量   施工工法  

摘要： ALC隔墙板是蒸压轻质混凝土的简称.这种隔墙板是一种性能良好的新型优越材料.它是以粉煤灰、水泥、石灰等为主要原材料,经过高温、高压、蒸汽养护而成的多气孔混凝土成品.隔音与吸音性能良好,具有极佳的保温隔热效果,材质较轻.作为非承重结构材料,完全满足在施工条件下对板材进行抗弯、抗裂及节点强度的要求,是一种容重轻、强度高的结构材料.本文对ALC隔墙板的施工技术应用进行研究.

关键词： Desmoplastic small round cell tumor   Submandibular gland   Small round blue cell tumors   Fine needle aspiration cytology   Literature review   FINE-NEEDLE-ASPIRATION   IN-SITU HYBRIDIZATION   DIAGNOSIS   CYTOLOGY   MANAGEMENT   FEATURES   CHAIN  

摘要： Background Desmoplastic small round cell tumor (DSRCT) is a sporadic, highly malignant tumor with a poor prognosis. The abdomen and pelvis have been reported as the primary localization sites. However, to the best of our knowledge, there are few reports on primary DSRCT in the submandibular gland. Case presentation We report a case of a 26-year-old Chinese man with a mass in the right submandibular gland. Imaging studies showed a hypoechoic mass in the right submandibular region. Intraoperative pathology revealed that the tumor tissue was composed of small round tumor cells and a dense desmoplastic stroma. On immunostaining, the tumor cells showed markers of epithelial, mesenchymal, myogenic, and neural differentiation. The EWSR1 gene rearrangement was detected by fluorescence in situ hybridization. Based on the overall morphological features and immunohistochemical findings, a final diagnosis of DSRCT was made. The patient was treated with comprehensive anti-tumor therapy mainly based on radiotherapy and chemotherapy. Conclusions DSRCT is an uncommon malignant neoplasm with rare submandibular gland involvement. In this report, we have described a case of DSRCT in the submandibular gland and reviewed the literature on DSRCT over the past 5 years. Considering the importance of differential diagnosis between DSRCT, especially with rare extra-peritoneal involvement, and small round blue cell tumors, a full recognition of the clinicopathological features will help to better diagnose this neoplasm.

关键词： Extracellular vesicles   Exosomes   Microvesicles   Embryo implantation   Endometrial cells   Endometrial receptivity   Embryo development   Proteomics   Ultracentrifugation   EXPRESSION   EXOSOMES   ADHESION   COMMUNICATION   FIBRONECTIN   FERTILIZATION   RECEPTIVITY   PEPTIDASE   GENES   CARGO  

摘要： Background Successful implantation is dependent on coordination between maternal endometrium and embryo, and the role of EVs in the required cross-talk cell-to-cell has been recently established. In this regard, it has been reported that EVs secreted by the maternal endometrium can be internalized by human trophoblastic cells transferring their contents and enhancing their adhesive and invasive capacity. This is the first study to comprehensively evaluate three EV isolation methods on human endometrial epithelial cells in culture and to describe the proteomic content of EVs secreted by pHEECs from fertile women. Methods Ishikawa cells and pHEECs were in vitro cultured and hormonally treated; subsequently, conditioned medium was collected and EVs isolated. Ishikawa cells were used for the comparison of EVs isolation methods ultracentrifugation, ExoQuick-TC and Norgen Cell Culture Media Exosome Purification Kit (n = 3 replicates/isolation method). pHEECs were isolated from endometrial biopsies (n = 8/replicate; 3 replicates) collected from healthy oocyte donors with confirmed fertility, and protein content of EVs isolated by the most efficient methodology was analysed using liquid chromatography-tandem mass spectrometry. EV concentration and size were analyzed by nanoparticle tracking analysis, EV morphology visualized by transmission electron microscopy and protein marker expression was determined by Western blotting. Results Ultracentrifugation was the most efficient methodology for EV isolation from medium of endometrial epithelial cells. EVs secreted by pHEECs and isolated by ultracentrifugation were heterogeneous in size and expressed EV protein markers HSP70, TSG101, CD9, and CD81. Proteomic analysis identified 218 proteins contained in these EVs enriched in biological processes involved in embryo implantation, including cell adhesion, differentiation, communication, migration, extracellular matrix organization, vasculature development, and reproductive processe

关键词： 郁金香   污染空气   阳台   拍打  

摘要： 窗帘拉开,阳光与我撞了个满怀。阳台上,金色的郁金香含苞欲放,娇嫩的花瓣微微绽开,美丽又骄傲。清风拂过,送来淡淡的清香。我舒服地伸了一个懒腰。多么惬意的早晨啊!"砰,砰……"楼上的阳台传来一阵拍打的声音。随后,棉絮和灰尘纷纷扬扬,从天而降。我躲避不及,被弄得灰头土脸。怒气在我的胸中翻腾,我像一个一点就着的炮仗。我伸长脖子,忍不住向楼上吼道:"拍什么拍,大早上的就知道污染空气!"可楼上的拍打声并没有停止。

关键词： 生态系统服务   评价   功能分区   InVEST模型   大清河-白洋淀流域  

摘要： 基于生态系统服务功能对流域生态环境进行功能分区是流域生态环境保护与修复的重要基础.本研究使用InVEST模型,对大清河-白洋淀流域2010、2015及2018年的生境质量、碳储量及土壤侵蚀等生态系统服务功能进行评价.结果表明:2010—2015年流域生态环境相对稳定;2015—2018年生境质量提升,土壤侵蚀缓解,但碳储量有所下降;流域内72.91%的区域处于中度敏感状态,3.99%的区域处于高度敏感状态,生态功能现状不容乐观.在此基础上叠加分析各子功能评价地图,将研究区划分为3个一级功能区及7个二级功能区,旨在今后对各功能区采取针对性的利用和管理策略,以维持和改善生境质量,为区域可持续发展提供支撑.

关键词： 挡浪墙   砼   沉降缝   漏浆  

摘要： 在典型施工中挡浪墙砼常出现松顶、云斑、底脚漏浆导致的蜂窝麻面、锈斑、沉降缝缝板处漏浆导致的砂陷麻面、粘皮、正斜面的气泡数量太多且较大等问题,分析原因,砼的外观质量得到改善。

关键词： 生态清洁小流域   功能分区   建设模式   叶巴沟   拉萨  

摘要： 生态清洁小流域是指在传统小流域综合治理基础上,将水资源保护、面源污染防治、农村垃圾及污水处理等结合到一起的一种新型综合治理模式。以西藏自治区达孜县叶巴沟小流域为例,提出了生态清洁小流域应采取"封-治-控"的建设模式,以期为拉萨地区生态清洁小流域建设提供参考。