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关键词： 金属多孔材料   建筑领域   节能门窗  

摘要： 金属多孔材料的性能特征多样,应用效果显著。基于此,文章对金属多孔材料进行了概述,研究了金属多孔材料在建筑领域的具体应用,分析了金属多孔材料未来的发展趋势,以期为相关人员提供借鉴与帮助。

关键词： 秦始皇陵兵马俑陪葬坑   夯土隔墙   夯土二层台   地宫形制   夯筑技术  

摘要： 秦始皇陵兵马俑陪葬坑中有大量夯土隔墙。从夯土隔墙的夯筑技术和功能两方面着手,辅之以隔墙内部结构,得出这种夯土隔墙承继于春秋战国时期墓葬建筑中的夯土二层台。在分析秦兵马俑坑隔墙所显示的俑坑结构特征的基础上,结合诸陪葬墓的形制等推测了秦始皇陵的地宫形制,并简述了秦汉时期夯筑技术的成熟与传播。

关键词： 契亲   契婿契女   契爹契娘  

摘要： 在婚俗基础上形成的契亲是一种模拟生物学血缘关系而产生的一种亲属关系,契爹契婿之间的身份定位可以超越血缘原则构建新型的人际关系,不会造成继嗣关系、财产继承关系,具有社会现实意义。也可以在血缘亲属基础上重构亲属关系,重新配置人际关系资源,成为文化生成的契亲亲属的第四个类型。

关键词： 房间隔缺损   人工智能   超声心动图   辅助诊断  

摘要： 目的探讨人工智能辅助诊断技术在超声心动图诊断房间隔缺损(ASD)中的应用价值。方法回顾性分析2020年6—9月首都医科大学附属北京安贞医院小儿心脏中心确诊的80例ASD患者的临床资料。另选取同期因心脏杂音行超声心动图检查并排除ASD的体检者39例。收集所有受试者的二维及彩色多普勒超声心动图静态图像,按60%和40%的比例划分为训练集和测试集,训练集分别在RESNET50(残差神经网络)、NSENET121(密集连接卷积网络)以及人工智能辅助诊断模型中进行训练。比较3种模型在测试集中对ASD的诊断准确率、假阴性率及假阳性率。结果训练集由44例ASD患者与27例体检者组成,测试集由36例ASD患者与12例体检者组成。RESNET50、DENSENET121及人工智能辅助诊断模型对ASD的诊断准确率分别为83.3%(40/48)、85.4%(41/48)、97.9%(47/48),假阴性率分别为2.8%(1/48)、16.7%(8/48)、2.8%(1/48),假阳性率分别为58.3%(28/48)、13.9%(6/48)、0(0/48)。3个模型对ASD的诊断准确率、假阴性率、假阳性率比较差异均有统计学意义(χ^(2)=6.05,P=0.04;χ^(2)=10.53,P=0.01;χ^(2)=29.67,P<0.01)。结论人工智能辅助诊断技术可提高超声心动图诊断ASD的准确率,有推广应用价值。

关键词： 高层建筑   内爬式塔式起重机   吊装工艺   顶升工艺  

摘要： 针对内爬式塔式起重机在高层建筑中的应用情况及施工注意事项,结合某在建高层建筑的工程实际情况,对内爬式塔式起重机进行总结。通过对内爬式塔式起重机的分类及施工工艺的介绍,为高层及超高层建筑提供可靠的参考。

关键词： 郁金香   向日葵   美人蕉   成长之路   阳台   花盆   自然万物   自然现象  

摘要： 阳台上的美人蕉长得强健,植株有半人高了。其实我很少打理它,除了偶尔浇些水,就是过段时间调转一下花盆方向。因为阳台向阳,临窗的枝叶明显向外舒展。植物向阳是自然现象,比如向日葵随太阳转动。很多植物的花朵,跟随着太阳,白天怒放,晚上合拢,如郁金香。利用阳光的力量,在一些植株弯曲时及时纠偏,是很多养花之人用过的方法。自然万物,包括人,成长之路皆与之类似。

关键词： Mink   Interferon-gamma   Monoclonal antibody   Hybridoma clones   Lymphocyte   ELISA method   IFN-GAMMA   CANINE-DISTEMPER   EXPRESSION   CLONING   VIRUS  

摘要： Due to their susceptibility to several human viruses, the mink has been proposed as potential animal models for the study of human viral infections. However, there are no specific monoclonal antibody (mAbs) currently available for the detection of mink-specific interferon-gamma (miIFN-gamma). The BALB/c mice were immunized intraperitoneally with purified recombinant miIFN-gamma protein. The splenocytes were obtained and fused with murine myeloma cells. Five of 24 hybridoma clones were obtained to produce mAbs steadily with the strongest affinity to recombinant miIFN-gamma protein. The isotype of the 31A, 31B and 31G were lgG 2b. The isotype of 44 and 46 were lgG 2a and 1. All five mAbs were. light chains. Western blotting and indirect ELISA method showed that 5 mAbs were positive to miIFN-gamma. Immunofluorescence showed that 2 mAbs (44 and 46) had a positive reaction to miIFN-gamma. The hybridoma clone 46 had the highest sensitivity for the detection of miIFN-gamma. Most importantly, our primary sandwich ELISA system (mAbs 46 and polyclonal antiserum) detected endogenous IFN-gamma in mink lymphocytes infected with canine distemper virus (CDV). We have thus developed a novel mAbs could recognize miIFN-gamma, and have demonstrated the first ELISA-based measurement of IFN-gamma in lymphocyte of the mink.

关键词： PD-L1 EXPRESSION   IMMUNE MICROENVIRONMENTS   TUMOR MICROENVIRONMENT   CLASSIFICATION   ATEZOLIZUMAB   CHEMOTHERAPY   RESISTANCE   BLOCKADE  

摘要： Metastatic tumors (MTs) may show different characteristics of the immune microenvironment from primary tumors (PTs) in non-small cell lung cancer (NSCLC). The heterogeneity of immune markers in metastatic NSCLC and its associated factors has not been well demonstrated. In this study, 64 surgically resected specimens of paired PTs and MTs were obtained from 28 patients with NSCLC. Multiplex immunofluorescence (mIF; panel including programmed death-ligand 1 (PD-L1), Cytokeratin, CD8, and CD68) was performed on whole sections. The heterogeneity of the immune contexture of PD-L1 expression, infiltrating lymphocytes, and immune-to-tumor cell distances was quantified via digital image analysis. In a quantitative comparison of MTs and corresponding PTs, MTs showed higher PD-L1 expression levels, lower density of CD8+ cytotoxic T lymphocytes (CTLs), and longer spatial distance between CTLs and tumor cells. Subgroup analysis, which associated clinical factors, revealed that the heterogeneity of immune markers was more obvious in extrapulmonary, metachronous, and treated MTs, while fewer differences were observed in intrapulmonary, synchronous, and untreated MTs. In particular, MTs showed significantly higher PD-L1 expression and lower lymphocyte infiltration in metastatic NSCLC with EGFR mutations. Prognosis analysis showed that an increased density of CD8+ CTLs in MTs was associated with better overall survival (OS). Therefore, significant discrepancies in PD-L1 expression and lymphocyte infiltration in metastatic NSCLC are most likely associated with temporal heterogeneity with a history of anti-treatment and correlated with EGFR mutations. The detection of immune markers in re-obtained metastatic specimens may be required for immunotherapy prediction in these patients with metastatic NSCLC.

关键词： Software-defined networking   Controller   Software-defined wireless sensor network   Distributed controllers   Wireless sensor network   TOPOLOGY DISCOVERY PROTOCOL   SECURITY CHALLENGES   DATA AGGREGATION   SOCIAL MEDIA   MANAGEMENT   SDWSN   COMMUNICATION   OPPORTUNITIES   CONTROLLERS   INTERFACE  

摘要： Software-defined networking (SDN) is widely perceived to simplify network management and monitoring. The introduction of the SDN model into wireless sensor networks (WSNs)-SDWSNs-helps the SDN controller perform intensive tasks. In contrast, sensor nodes will only perform forwarding tasks to address a WSN's many problems and challenges, such as energy consumption, reliability, and consistency. This study conducts a review following a systematic process to identify the development concerning the architectural design of SDWSNs with a particular emphasis on the distributed control and programmability features of sensor nodes. A total of 84 papers from reputable databases were evaluated through thematic analysis. The findings revealed the relationship between an SDN and a WSN from conceptual perspectives, the taxonomy of research studies conducted for SDWSNs, and the various architectural development of SDWSNs proposed in the literature from programmable sensor nodes' perspectives, software sensor nodes, and distributed control. Moreover, the open issues and challenges faced by SDWSNs' solutions still include the inherent problems of optimal energy consumption, security, and distributed implementations for various applications.

关键词： MICROSCOPIC RESIDUAL DISEASE   POSTOPERATIVE RADIOTHERAPY   MARGIN STATUS   SURVIVAL   CHEMOTHERAPY   THERAPY   SOCIETY   IMPACT  

摘要： Irradical (R1-2) resection for non-small cell lung cancer (NSCLC) is associated with a dismal prognosis. Adjuvant treatment attempts to improve survival outcomes, but evidence on the optimal strategy is lim-ited. The purpose of this study was to compare overall survival (OS) between different adjuvant treatment strategies in these patients. Out of 8,528 patients with newly diagnosed NSCLC from 2015-2018, those with an R1-2 resection were identified from the Netherlands Cancer Registry. First, OS was compared between adjuvant treatment groups 'no therapy', 'radiotherapy (RT) only', 'chemotherapy only', and 'chemo-and radiotherapy (CRT)' using multinomial propensity score-weighted Cox regression analysis. Second, three 1:1 propensity score -matched sets were created for chemotherapy vs no chemotherapy, RT only vs no therapy, and CRT vs chemotherapy only. Kaplan-Meier and Cox regression analyses for OS were performed in each set. With a median follow-up of 23 months, 427 patients were selected. In the weighted regression analysis, compared to no adjuvant therapy, chemotherapy and CRT were associated with improved OS (HR 0.41, 95%CI: 0.22-0.76; and HR 0.55, 95%CI: 0.37-0.81, respectively), whereas RT was not (HR 1.04, 95%CI: 0.731.50). In the matched sets, OS was improved after chemotherapy (+/-RT) compared to no chemotherapy (HR 0.47, 95%CI: 0.32-0.69). No OS difference was observed between matched groups of RT only vs no adjuvant therapy (HR 1.13, 95%CI: 0.74-1.72), nor for CRT vs chemotherapy only (HR 1.37, 95%CI: 0.70-2.71). Adjuvant chemotherapy, but not radiotherapy, improves survival after an R1-2 resection in stage I-III NSCLC. (C) 2021 The Author(s). Published by Elsevier Inc.