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关键词： 检验检疫局   党组织   和谐   机关   分发   检验检疫事业   政治素质   领导班子  

摘要： 一、在构建和谐机关中,各级党组织具有决定性作用 1.＂家和万事兴＂的治局理念提高了广大干部职工的政治素质,为建设和谐机关奠定了思想基础。2008年,广东检验检疫局新领导班子一组成,党组书记、局长李延辉同志就有针对性地提出了＂家和万事兴＂的治局理念。两年来,＂家和万事兴＂的治局理念已成为广东检验检疫事业发展的保证。

关键词： Negative affectivity   Emotion regulation   Anxiety   Depression   Youth   Structural equation modeling  

摘要： The relationship between negative affectivity (NA) and emotion regulation (ER) in determining anxiety and depressive symptomatology was examined in a large (n = 1441) sample of adolescents (12-17 years old). Two models, diverging only as to inclusion or exclusion of a path from NA to negative ER, were analyzed through structural equation modeling: the goal was to explore the mediational or non-mediational role of ER in determining anxiety symptoms. The models yielded similar adequate fit to data, indicating that both NA and negative ER contribute to anxiety symptoms which, in turn, significantly determine depressive symptomatology. The mediational model better captures the relationships revealed in the data, with NA determining negative ER to a great extent Additionally, most individuals scoring highly in NA also tend to score highly in negative ER, indicating that adolescents with heightened NA are prone to a dysfunctional style of ER. (C) 2010 Elsevier Ltd. All rights reserved.

关键词： Support Vector Machine   Random Forest   Simulated Dataset   Average Classification Accuracy   Recursive Feature Elimination  

摘要： Background: Data generated using 'omics' technologies are characterized by high dimensionality, where the number of features measured per subject vastly exceeds the number of subjects in the study. In this paper, we consider issues relevant in the design of biomedical studies in which the goal is the discovery of a subset of features and an associated algorithm that can predict a binary outcome, such as disease status. We compare the performance of four commonly used classifiers (K-Nearest Neighbors, Prediction Analysis for Microarrays, Random Forests and Support Vector Machines) in high-dimensionality data settings. We evaluate the effects of varying levels of signal-to-noise ratio in the dataset, imbalance in class distribution and choice of metric for quantifying performance of the classifier. To guide study design, we present a summary of the key characteristics of 'omics' data profiled in several human or animal model experiments utilizing high-content mass spectrometry and multiplexed immunoassay based techniques. Results: The analysis of data from seven 'omics' studies revealed that the average magnitude of effect size observed in human studies was markedly lower when compared to that in animal studies. The data measured in human studies were characterized by higher biological variation and the presence of outliers. The results from simulation studies indicated that the classifier Prediction Analysis for Microarrays (PAM) had the highest power when the class conditional feature distributions were Gaussian and outcome distributions were balanced. Random Forests was optimal when feature distributions were skewed and when class distributions were unbalanced. We provide a free open-source R statistical software library (MVpower) that implements the simulation strategy proposed in this paper. Conclusion: No single classifier had optimal performance under all settings. Simulation studies provide useful guidance for the design of biomedical studies involving high-di

关键词： 安全生产   检测检验   矿山安全  

摘要： 对安全生产检测检验在矿山安全生产中所发挥的作用进行了分析,安全生产检测检验为政府部门监管监察提供技术支撑、为矿用产品安全认证提供测试数据,为矿山安全生产事故调查提供物证分析依据,是淘汰矿山在用落后设备、消除安全生产事故隐患的重要手段,为安全评价提供技术支持,为矿山安全生产提供技术咨询服务。在安全生产形势仍然严峻的大背景下,随着全社会对矿山安全生产的日益重视,安全生产检测检验在矿山安全生产中必将发挥越来越重要的作用。

关键词： 尿液分析   质量控制   实验室检查  

摘要： 为保证尿液的检验质量，我们就必须重视尿液分析的质量控制，才能保证给临床提供可靠的实验室数据。辅助临床治疗用药。从中更好地发挥基础医学检验的作用。

关键词： 检验医学   实验室信息系统   实习教学  

摘要： 实验室信息管理系统(LIS)的广泛应用给检验医学临床实习教学工作带来更多的机遇和挑战,从实习教学的角度,初步探讨了LIS系统在检验医学实习教学中的作用。

关键词： 检验科   微生物检验   感染控制   作用  

摘要： 随着现代信息技术和医学生物学,特别是医学分子生物学的发展,医学微生物学检验技术近年来也获得了长足的进步,并逐渐成为指导临床感染诊断和治疗的重要依据.临床微生物学工作者不仅要完成检验科工作,还要完成有关的临床工作,成为感染控制和抗生素应用的参谋和顾问.文章从对微生物检验的认识、监测、诊断等方面分析了微生物检验在感染控制中的做法和作用.

关键词： 石油美元   货币选择   石油交易   SDRS  

摘要： 20世纪70年代以来,美元一直垄断着石油计价权,石油美元给石油输出国带来了巨额的财富,同时也将美国扶上了全球霸主的地位,使美国在石油交易中享有特权,并控制了石油价格。但是,近几年随着美元的不断贬值,特别是2008年全球金融危机爆发后,让世界多数国家对石油美元产生了强烈的不满,石油美元面临价格、信任、投资危机。总结历史,目前石油美元暂时是不可代替的,各国可以通过签订双边货币协议来缓解石油美元带来的负面影响,最终还是应设立超主权储备货币来代替美元以达成国际货币体系改革的理想目标。

关键词： 连锁加盟   合同诈骗   侦查  

摘要： 连锁加盟式的合同诈骗已经不是犯罪分子非法敛财的新鲜手段,但是随着近一段时间"炒房热"的逐步退温,民间资本逐渐转向更为理性的项目,如投资连锁加盟店。犯罪分子趁机打着连锁加盟的旗号,对手中有部分闲余资金的群众大肆进行诈骗,犯罪手法更加隐蔽,社会危害性更大。文章拟从连锁加盟式合同诈骗的犯罪手法展开分析,以企对此类案件的侦查、打击进行研究。

关键词： cirrhosis   hepatocarcinoma   matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF)   proteomic signature   Random Forest   variability  

摘要： Background: Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) proteomic signature might be of interest for the early detection and staging of hepatocellular carcinoma (HCC). However, published procedures have been criticized for the lack of data about analytical reproducibility, and the use of inadequate data processing. Methods: MALDI-TOF profiling of peptides bound to serum albumin ("albuminome'') was performed using 90 mu L of serum from 45 study subjects (HCV-related cirrhosis, small, unifocal HCCs and advanced HCCs). To overcome the large intra-sample variability, a Quality Assurance protocol was implemented, and 4-8 samples for each subject were processed and analyzed. Overall, 522 subject samples and 299 quality-control spectra were analyzed. A machine-learning approach (Random Forest) was applied to analyze the data sets. Results: Mean intra-sample coefficient of variation (CV) of the analytical procedure was 17.6%-30.0%;inter-subject CV was in the range 48.8%-71.3% among the three study groups. The Random Forest procedure correctly classified 433/522 "patient samples'' and 295/299 "reference samples'';43/45 patients were correctly classified following this approach. Conclusions: Our data suggest that, notwithstanding the large analytical variability found, multiple proteomic profiles obtained from each subject can differentiate cirrhosis with and without HCC, and HCCs with and without vascular invasion, warranting further investigation in a prospective setting. Clin Chem Lab Med 2010;48:1319-26.