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关键词： 血液检验   贫血诊断   鉴别  

摘要： 目的：探讨血液检验在贫血鉴别诊断中的应用和作用方法：从我院2010年9月到2013年9月接收并治疗的贫血患者中抽取110例,随机分为观察组和对照组,每组55例,观察组全部为地中海贫血患者,对照组全部为缺铁性贫血患者,对两组患者行相同检测,然后比较两组患者的指标差异. 结果：观察组中RBC和RBC/MCV 均民享高于对照组,观察组检测灵敏度、符合率以及特异性较对照组低,其中p〈0.05,差异具有统计学意义.结论：对于贫血的鉴别诊断,血液检验能够对RBC、RBC/MCV 等指标进行检测,同时对灵敏度、符合率等进行分析,能够更加高效的进行诊断,对于贫血的不同类型作出鉴别,是一种科学、高效的临床医学检验方法,值得在贫血患者的临床鉴别诊断中运用和推广.

关键词： 错别字   文书检验   作用  

摘要： 文书检验工作运用检验学的理论和方法,在如今的刑事案件和民事案件中起着举足轻重的作用。特别是在检察机关的自侦案件中,它能够为其提供可靠的线索和证据。笔者结合自己的实际工作,对如何运用文书检验为侦查提供方向,如何运用错别字的特征完成笔迹检验,作了简单论述。

关键词： Stand-off LIBS   Classification   PCA   LDA   Cultural heritage   LIBS   ALLOYS  

摘要： Focusing on historical aspect, during archeological excavation or restoration works of buildings or different structures built from bricks it is important to determine, preferably in-situ and in real-time, the locality of bricks origin. Fast classification of bricks on the base of Laser-Induced Breakdown Spectroscopy (LIBS) spectra is possible using multivariate statistical methods. Combination of principal component analysis (PCA) and linear discriminant analysis (LDA) was applied in this case. LIBS was used to classify altogether the 29 brick samples from 7 different localities. Realizing comparative study using two different LIBS setups - stand-off and table-top it is shown that stand-off LIBS has a big potential for archeological in-field measurements. (C) 2014 Elsevier B.V. All rights reserved.

关键词： analysis of algorithms   suboptimal algorithms   marketing   product policy   fractional programming   attraction model   assortment optimization   DYNAMIC ASSORTMENT   REVENUE MANAGEMENT   RETAIL ASSORTMENTS   MARKET SHARE   CHOICE MODEL   INVENTORY   DEMAND   SUBSTITUTION   ALGORITHM   RATIOS  

摘要： Motivated by retailers' frequent introduction of new items to refresh product lines and maintain their market shares, we present the assortment packing problem in which a firm must decide, in advance, the release date of each product in a given collection over a selling season. Our formulation models the trade-offs among profit margins, preference weights, and limited life cycles. A key aspect of the problem is that each product is short-lived in the sense that, once introduced, its attractiveness lasts only a few periods and vanishes over time. The objective is to determine when to introduce each product to maximize the total profit over the selling season. Even for two periods, the corresponding optimization problem is shown to be NP-complete. As a result, we study a continuous relaxation of the problem that approximates the problem well, when the number of products is large. When margins are identical and product preferences decay exponentially, its solution can be characterized: it is optimal to introduce products with slower decays earlier. The structural properties of the relaxation also help us to develop several heuristics, for which we establish performance guarantees. We test our heuristics with data on sales and release dates of women's handbags from an accessories retailer. The numerical experiments show that the heuristics perform very well and can yield significant improvements in profitability.

关键词： Breast cancer   Receptor concordance   ER   PR   HER2   Random forest   IHC   Biomarkers   qPCR   ESTROGEN-RECEPTOR STATUS   GENE-EXPRESSION   MESSENGER-RNA   PREDICTOR   MODEL   IMMUNOHISTOCHEMISTRY   SURVIVAL   THERAPY  

摘要： Breast cancers are categorized into three subtypes based on protein expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2/ERBB2). Patients enroll onto experimental clinical trials based on ER, PR, and HER2 status and, as receptor status is prognostic and defines treatment regimens, central receptor confirmation is critical for interpreting results from these trials. Patients enrolling onto experimental clinical trials in the metastatic setting often have limited available archival tissue that might better be used for comprehensive molecular profiling rather than slide-intensive reconfirmation of receptor status. We developed a Random Forests-based algorithm using a training set of 158 samples with centrally confirmed IHC status, and subsequently validated this algorithm on multiple test sets with known, locally determined IHC status. We observed a strong correlation between target mRNA expression and IHC assays for HER2 and ER, achieving an overall accuracy of 97 and 96 %, respectively. For determining PR status, which had the highest discordance between central and local IHC, incorporation of expression of co-regulated genes in a multivariate approach added predictive value, outperforming the single, target gene approach by a 10 % margin in overall accuracy. Our results suggest that multiplexed qRT-PCR profiling of ESR1, PGR, and ERBB2 mRNA, along with several other subtype associated genes, can effectively confirm breast cancer subtype, thereby conserving tumor sections and enabling additional biomarker data to be obtained from patients enrolled onto experimental clinical trials.

关键词： SELECTION   REGULARIZATION   VERIFICATION   MULTICLASS   IMPROVER   IMPACT  

摘要： Introduction: The widespread application of microarray experiments to cancer research is astounding including lung cancer, one of the most common fatal human tumors. Among non-small cell lung carcinoma (NSCLC), there are two major histological types of NSCLC, adenocarcinoma (AC) and squamous cell carcinoma (SCC). Results: In this paper, we proposed to integrate a visualization method called Radial Coordinate Visualization (Radviz) with a suitable classifier, aiming at discriminating two NSCLC subtypes using patients' gene expression profiles. Our analyses on simulated data and a real microarray dataset show that combining with a classification method, Radviz may play a role in selecting relevant features and ameliorating parsimony, while the final model suffers no or least loss of accuracy. Most importantly, a graphic representation is more easily understandable and implementable for a clinician than statistical methods and/or mathematic equations. Conclusion: To conclude, using the NSCLC microarray data presented here as a benchmark, the comprehensive understanding of the underlying mechanism associated with NSCLC and of the mechanisms with its subtypes and respective stages will become reality in the near future.

关键词： 医学检验   分子生物传感器   分子蛋白组学   分子生物芯片技术  

摘要： 从近几年分子生物学方法的运用来看,以核酸生化作为基础的新技术成为了当前医学检验的最新方法,在医学检验领域上得到了广泛的应用。笔者在前人相关研究的基础上,结合自己的实际工作经验和认识,谈谈分子生物学中的几个相关技术,希望读者可以加深对此的认识和了解。

关键词： 《农作物种子检验规程》   棉花种子   国家质量监督检验检疫总局   《农作物种子质量标准》   国家技术监督局   管理   企业   GB/T  

摘要： 种子检验是指采取科学的技术和方法，对种子质量进行分析研究，判断其优劣，评定其种用价值的过程[1]。目前，我国棉花种子检验方法主要为原国家技术监督局（现为国家质量监督检验检疫总局）1995年发布的《农作物种子检验规程》即GB/T 3543.1~3543.7-1995，检测项目主要为棉花种子的纯度、净度、发芽率、水分等指标，种子质量执行国家质量监督检验检疫总局2008年发布的《农作物种子质量标准》即GB 4407.1-2008国家强制标准，质量判定规则执行国家质量监督检验检疫总局2006年发布的《农作物种子标签通则》即GB 20464-2006的规定。

关键词： 财富作用   习惯消费   住宅房地产  

摘要： 文章基于习惯性消费的模型假设,采用新的模型方法,对我国住宅房地产对加总消费影响规模重新进行了估计。模型考虑了消费增长相对财富水平变化的滞后性,以此区分了短期和长期的财富作用。研究发现:区别于传统方法,我国住宅房地产的短期财富作用为负,而长期财富作用为正的;相较于金融资产财富对加总消费的影响,住宅房地产的财富作用相对较小。