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关键词： chemical shift perturbation   cross saturation   fragment based screening   initiation factors   nuclear magnetic resonance   paramagnetic relaxation enhancement   residual dipolar couplings   small angle X-Ray scattering reconstitution assay   translation initiation   weak interactions  

摘要： Weak protein-protein interactions are critical in numerous biological processes. Unfortunately, they are difficult to characterize due to the high concentrations required for the production and detection of the complex population. The inherent sensitivity of NMR spectroscopy to the chemical environment makes it an excellent tool to tackle this problem. NMR permits the exploration of interactions over a range of affinities, yielding essential insights into dynamic biological processes. The conversion of messanger RNA to protein is one such process that requires the coordinated association of many low-affinity proteins. During start codon recognition, eukaryotic initiation factors assemble into high-order complexes that bind messanger RNA and bring it to the ribosome for decoding. Many of the structures of the eukaryotic initiation factors have been determined;however, little is known regarding the weak binary complexes formed and their structure-function mechanisms. Herein, we use start codon recognition as a model system to review the relevant NMR methods for the characterization of weak interactions and the development of small molecule inhibitors.

关键词： 检验医学   社区   卫生服务   运行模式   作用   应用   分析  

摘要： 目的:探析检验医学在社区卫生服务中的运行模式与作用。方法:选取18个社区的1150名人员,其中,社区医护工作人员200名,社区患者或居民950名,采用问卷调查方法进行调查分析。结果:检验医学在社区卫生服务应用中,主要以开展常规检验为主,其中,约96%的社区医护工作人员认为,检验医学进行社区常规卫生检验服务应用,有利于疾病的及早诊断,并且有利于提高医护人员的治疗水平;约97%的的社区患者或居民认为,检验医学用于进行社区常规检验项目开展,为社区群众就医提供了很大的便利性。结论:检验医学在社区卫生服务中的运行应用,受到社区医护人员以及患者、居民的普遍认可,具有较大的积极作用和意义。

关键词： 生化检验   肾上腺皮质疾病   诊断作用  

摘要： 目的:对生化检验在肾上腺皮质疾病诊断中的作用进行探讨和分析。方法:选择2012年2月至2013年9月在我院进行治疗的70例肾上腺皮质疾病患者的临床资料进行研究和分析。将这些患者分为对照组和研究组(对照组20例患者,研究组50例患者),为对照组患者进行常规检验,对研究组患者进行生化检验,对两组患者进行检验的准确率进行观察和分析。结果:在对照组患者中有15例患者检验有效,有5例患者检验无效,检验的有效率为75%。在研究组患者中有48例患者检验有效,有2例患者检验无效,检验的有效率为96%。两组患者检验的有效率相比较,差异显著,具有统计学意义(P<0.05)。结论:对肾上腺皮质疾病患者进行生化检验能显著提高诊断的准确率,值得在临床上推广应用。

关键词： process control charts   pattern recognition   neural networks   fitted line  

摘要： The correct, prompt recognition and analysis of unnatural and significant patterns in Schewhart's control charts are very important since they remind out-of-control conditions. In fact, pattern extraction increases the sensitivity of charts when identifying out of control conditions. Artificial neural networks have been used to identify unnatural patterns in many research studies due to their high efficiency in pattern recognition. In most of such studies, there is a significant risk of misclassification of highly sensitive patterns. To put it more clearly, the proposed models offered for the recognition of patterns with low parametric coefficients are mistaken. This study, offers a model for the recognition and analysis of basic patterns in process control charts using LVQ and MLP networks along with a fitted line analysis. In this model, not only does risk of misclassification at different levels of sensitivity decrease remarkably, but there will also be the possibility for recognition and analysis when basic pattern occur simultaneously. The efficiency and effectiveness of the model are shown by conducting tests based on simulation.

关键词： URBAN planning   REMOTE-sensing images   DATA analysis   DECISION trees  

摘要： Understanding the factors that influence the performance of classifications over urban areas is of considerable importance to applications of remote-sensing-derived products in urban design and planning. We examined the impact of training sample selection on a binary classification of urban and nonurban for the Denver, Colorado, metropolitan area. Complete coverage reference data for urban and nonurban cover were available for the year 1997, which allowed us to examine variability in accuracy of the classification over multiple repetitions of the training sample selection and classification process. Four sampling designs for selecting training data were evaluated. These designs represented two options for stratification (spatial and class-specific) and two options for sample allocation (proportional to area and equal allocation). The binary urban and nonurban classification was obtained by employing a decision tree classifier with Landsat imagery. The decision tree classifier was applied to 1000 training samples selected by each of the four training data sampling designs, and accuracy for each classification was derived using the complete coverage reference data. The allocation of sample size to the two classes had a greater effect on classifier performance than the spatial distribution of the training data. The choice of proportional or equal allocation depends on which accuracy objectives have higher priority for a given application. For example, proportionally allocating the training sample to urban and nonurban classes favoured user's accuracy of urban whereas equally allocating the training sample to the two classes favoured producer's accuracy of urban. Although this study focused on urban and nonurban classes, the results and conclusions likely generalize to any binary classification in which the two classes represent disproportionate areas.

关键词： 计量   检验  

摘要： 阐述了计量和检验的定义,分析了计量工作在产品质量检验中的作用。产品质量检验离不开依靠计量工作获取的准确可靠的数据,企业应完善并做好计量工作。

关键词： 临床输血学   检验教学   临床实践   医学检验专业   医院输血科   应用型人才   医学科学技术   临床输血工作  

摘要： 随着社会经济和医学科学技术的发展，社会对从事输血医学研究和临床输血工作人才的需求发生了变化，对培养临床输血技术应用型人才的输血医学教育也提出了新的要求和挑战。目前在各级医院输血科工作的人员绝大部分是检验专业毕业生。《临床输血学检验》是医学检验专业近年为适应学科进展以及我国检验专业教育改革的需要［1］，面向医院输血科（血库）、血站及血制品单位相关岗位实际所需而设的一门课程。输血科、血站是操作性很强的科室，必须具备很强的临床技能才能胜任输血科、血站实验室的各项工作，成为合格的输血工作者。笔者于2009～2011年在安徽省血液中心临床实践，掌握临床专业技能，完善教师自身知识结构的同时，体会了临床实践在临床输血学检验课程教学的作用，并在教学过程中采取一定措施，取得满意的教学效果。

关键词： 十八大精神   食药检机构   办公室  

摘要： 目的探析食品药品检验机构办公室在落实十八大精神中的重要作用。方法结合首都食品药品检验机构工作任务,树立三种意识、锻炼四种素质、提高五种能力等方面进行阐述。结果与结论办公室要以十八大精神为指引,以新的思路、新的举措、新的作为切实提升办公室的服务质量和水平。

关键词： 浙江省   文化产业   作用机理检验   实证研究   对策  

摘要： 运用Eviews软件对2000-2012年浙江省文化产业对经济发展影响相关数据的分析结果表明:文化、体育、娱乐业从业人数、电影放映场次、图书馆、博物馆和文物保护单位的固定资产原值、有线电视落户率、报纸、杂志和图书印发数等对浙江经济发展明显促进作用。同时,浙江经济的发展会促进电影放映场次、有线电视落户数增加。浙江省应加强文化产业专业人才的培养,改善娱乐设施建设,扩建图书馆、博物馆和文物保护单位,进一步推进有线电视入户,设法提高报刊杂志的订阅数,创造良好的软环境,以促使文化产业与地区经济更好地协调发展。

关键词： 检验检疫   知识型人才   “心理契约”   管理策略  

摘要： 随着检验检疫事业的发展与改革,作为知识载体的知识型人才,他们所拥有的知识对检验检疫事业的发展至关重要。对于知识型人才来说,能否有效地工作,是否会对检验检疫事业萌生责任感、忠诚心、热情和满足感,在很大程度上取决于组织与人才之间心理契约的实现程度。在分析知识型人才激励现状及传统激励理论局限的基础上,借助心理契约理论,可以提出检验检疫知识型人才管理的相关对策。