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关键词： 检验检疫   国际物流   作用  

摘要： 在经济快速发展的今天,国际物流行业得到了很大的成功,创造的效益是非常突出的。可是为了在国际物流当中获得更多的盈利,必须有效地完成安全工作,应主动为检验检疫提供更多的数据、信息、资料,让检验体系更加健全,在检疫的手段上保持多元化,将各类危险因素彻底消除。要有效地落实检验检疫工作。文章针对检验检疫在国际物流中的作用展开讨论,并提出合理化建议。

关键词： Cluster Newton method   inter-individual variability   irinotecan(CPT-11)   neutropenia   physiologically-based pharmacokinetic modeling   virtual clinical study   CELL LUNG-CANCER   CLUSTER NEWTON METHOD   BODY-SURFACE-AREA   ACTIVE METABOLITE   PHASE-II   TOXICITY   HUMANS   CYTOCHROME-P450   IDENTIFICATION   CHEMOTHERAPY  

摘要： To establish a physiologically-based pharmacokinetic (PBPK) model for analyzing the factors associated with side effects of irinotecan by using a computer-based virtual clinical study (VCS) because many controversial associations between various genetic polymorphisms and side effects of irinotecan have been reported. To optimize biochemical parameters of irinotecan and its metabolites in the PBPK modeling, a Cluster Newton method was introduced. In the VCS, virtual patients were generated considering the inter-individual variability and genetic polymorphisms of enzymes and transporters. Approximately 30 sets of parameters of the PBPK model gave good reproduction of the pharmacokinetics of irinotecan and its metabolites. Of these, 19 sets gave relatively good description of the effect of UGT1A1 *28 and SLCO1B1 c.521T > C polymorphism on the SN-38 plasma concentration, neutropenia, and diarrhea observed in clinical studies reported mainly by Teft et al. (Br J Cancer. 112(5):857-65, 20). VCS also indicated that the frequency of significant association of biliary index with diarrhea was higher than that of UGT1A1 *28 polymorphism. The VCS confirmed the importance of genetic polymorphisms of UGT1A1 *28 and SLCO1B1 c.521T > C in the irinotecan induced side effects. The VCS also indicated that biliary index is a better biomarker of diarrhea than UGT1A1 *28 polymorphism.

关键词： Autism   Peer mediated intervention   Social interaction   Victimization   YOUNG-ADULTS   ADOLESCENTS   CHILDREN   BEHAVIOR   YOUTH   EXPERIENCES   CONNECTIONS   STRATEGIES   ENGAGEMENT   EMPLOYMENT  

摘要： Developing positive peer relationships is important. Unfortunately, due to challenges in social communication and increased complexity of peer groups during adolescence, many secondary students with autism spectrum disorder (ASD) engage in limited positive social interactions with peers. This study examined the effects of a peer network intervention implemented with three high school students with ASD. A multiple-baseline across participants design was used to evaluate the intervention on initiations and responses to and from students with ASD. The impact on frequency of victimization of students with ASD was also explored. Results indicate peer networks are effective at increasing social interactions of secondary students with ASD and provide preliminary support for the use of peer networks to reduce rates of bullying victimization.

关键词： Somatoform symptoms   Psychological disorders   Depression   Anxiety   Psychological distress   Factor mixture modeling   FUNCTIONAL SOMATIC SYNDROMES   FACTOR MIXTURE-MODELS   PRIMARY-CARE PATIENTS   PSYCHOSOMATIC SYMPTOMS   DEPRESSION   ANXIETY   PREVALENCE   DETERMINANTS   ASSOCIATION   VALIDATION  

摘要： In order to identifying somatoform symptoms profiles, classifying study population and evaluating of psychological disorders in extracted classes, we carried out a cross-sectional study on 4762 Iranian adults. Somatoform symptoms were assessed using a comprehensive 30-items questionnaire and psychological disorders were evaluated by 12-item General Health Questionnaire (GHQ-12) and Hospital Anxiety and Depression Scale (HADS) questionnaires. Factor analysis and factor mixture modeling (FMM) were used for data analysis. Four somatoform symptoms profiles were extracted, including 'psycho-fatigue', 'gastrointestinal', 'neuro-skeletal' and `pharyngeal-respiratory'. According to FMM results, a two-class four-factor structure, based somatoform symptoms, was identified in our study population. Two identified classes were labeled as "low psycho-fatigue complaints" and "high psycho-fatigue complaints". The scores of psychological disorders profile was significantly associated with four somatoform symptoms profiles in both classes; however the stronger relationship was observed in high psycho-fatigue complaints class. The prevalence of all the somatoform symptoms among participants assigned to the "high psycho-fatigue complaints" class was significantly higher than other class. We concluded that somatoform symptoms have a dimensional-categorical structure within our study population. Our study also provided informative pathways on the association of psychological disorders with somatoform symptoms. These findings could be useful for dealing with treatment's approaches.

关键词： oncology   PARP inhibitors   AstraZeneca   Merck  

摘要： The article reports the merger between AstraZeneca and Merck & Co. in order to expand the application of Lynparza, a small-molecule PARP inhibitor, to treat ovarian cancer.

关键词： 检测技术   稽查打假   作用  

摘要： 在食品稽查打假中,需要运用合理化方法检测食品质量和安全,科学评估食品质量和安全性能,发挥高质量的食品检测技术的重要作用。

关键词： 检验实验室   质量管理   食品   检测过程   消费者   标准方法   检验参数   监督检测  

摘要： 市场上各式各样食品流入消费者手中时,都要经过检测环节,在检测过程中,实验室按标准方法检测,严格审查每项检验参数,在很大程度上影响食品质量管理。食品监督检测后,食品流入消费者市场容易被消费者接受,消费者才能放心食用采购食品,不追究食品实验室在质量管理检测所得到的具体数据。消费者无条件信任,实际上赋予食品检验实验室在质量管理中更多责任,食品检验实验室只有在质量管理中认真履行自己的职责,

关键词： nucleic acids   oligonucleotides   RNA   CordenPharma   GE  

摘要： The article reports on a collaboration between CordenPharma International and GE Healthcare's Dharmacon division to provide an end-to-end service for oligonucleotide-based drug discovery.

关键词： Surface defect   Support vector machine   Random subspace   Bayes classifier  

摘要： Nowadays, surface defect detection systems for steel strip have replaced traditional artificial inspection systems, and automatic defect detection systems offer good performance when the sample set is large and the model is stable. However, the trained model does work well when a new production line is initiated with different equipment, processes, or detection devices. These variables make just tiny changes to the real-world model but have a significant impact on the classification result. To overcome these problems, we propose an evolutionary classifier with a Bayes kernel (BYEC) that can be adjusted with a small sample set to better adapt the model for a new production line. First, abundant features were introduced to cover detailed information about the defects. Second, we constructed a series of support vector machines (SVMs) with a random subspace of the features. Then, a Bayes classifier was trained as an evolutionary kernel fused with the results from the sub-SVM to form an integrated classifier. Finally, we proposed a method to adjust the Bayes evolutionary kernel with a small sample set. We compared the performance of this method to various algorithms; experimental results demonstrate that the proposed method can be adjusted with a small sample set to fit the changed model. Experimental evaluations were conducted to demonstrate the robustness, low requirement for samples, and adaptiveness of the proposed method.